3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester
Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-5-carboxylate
CAS: 71145-03-4
Molecular Formula: C16H15F3N2O4
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Names and Identifiers
| Name | Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-5-carboxylate |
| Synonyms | Methyl 2,6-dimethyl-3-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-5-carboxylate methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-[TRIFLUOROMETHYL]PHENYL)PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2'-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID, METHYL ESTER 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester |
| CAS | 71145-03-4 |
| InChI | InChI=1/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,12-13H,1-3H3/t12?,13-/m1/s1 |
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Physico-chemical Properties
| Molecular Formula | C16H15F3N2O4 |
| Molar Mass | 356.3 |
| Density | 1.3548 (estimate) |
| Melting Point | 166 °C |
| Boling Point | 429.2±45.0 °C(Predicted) |
| Flash Point | 198.3°C |
| Water Solubility | Soluble in DMSO at 20mg/ml. Also soluble in methanol or ethanol at 60mg/ml. Insoluble in water |
| Solubility | Soluble in DMSO |
| Vapor Presure | 9.53E-07mmHg at 25°C |
| Appearance | Yellow solid. |
| Color | Yellow |
| pKa | -3.43±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.545 |
| Use | Bay K 8644 is a potent, selective activator of L-type Ca2 channel with IC50 of 17.3 nM. |
| In vitro study | Bay K 8644, as an agonist of L-type calcium ions, increases the resting tension of mesenteric arteries taken from rats. |
| In vivo study | Bay K 8644 can induce the small contraction of the aorta of 5 weeks old, 3 months old, 1 year old, 1.5 age wistar-kyoto rats, which is not affected by the age of the rats. |
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | US5655000 |
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.807 ml | 14.033 ml | 28.067 ml |
| 5 mM | 0.561 ml | 2.807 ml | 5.613 ml |
| 10 mM | 0.281 ml | 1.403 ml | 2.807 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.561 ml |
Last Update：2024-01-02 23:10:35
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Cell Experiment
1: Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR. Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. Chin J Physiol. 2013 Dec 31;56(6):318-25. doi: 10.4077/CJP.2013.BAB161. Erratum in: Chin J Physiol. 2014 Feb 28;57(1):60. PubMed PMID: 24495178.2: Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. J Biol Chem. 2010 Mar 5;285(10):6996-7005. doi: 10.1074/jbc.M109.059865. PubMed PMID: 20054004; PubMed Central PMCID: PMC2844149.3: Turner CP, Debenedetto D, Liu C. NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644. Neurosci Lett. 2009 Feb 6;450(3):292-5. doi: 10.1016/j.neulet.2008.12.002. PubMed PMID: 19070650; PubMed Central PMCID: PMC2699449.
Last Update：2023-08-16 21:32:38
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester - Reference Information
| introduction | BAY K8644 is an L-type Ca2 channel activator with positive inotropic and vasoconstrictive effects, and can be used as an active L-type calcium channel agonist. |
| biological activity | Bay K 8644 is a highly selective l-type calcium channel agonist with EC50 of 17.3 nM. |
| target | TargetValue L-type calcium channel (in the isolated field-stimulated vas deferens of the mouse) 17.3nM(EC50) |
| Target | Value |
| L-type calcium channel (in the isolated field-stimulated vas deferens of the mouse) | 17.3nM(EC50) |
| in vitro study | Bay K 8644, as an agonist of l-type calcium ions, improves the resting tension of mesenteric arteries taken from rats. |
| in vivo study | Bay K 8644 can induce small contraction of aorta in rats wistar-kyoto 5 weeks of age, 3 months of age, 1 year and 1.5, which is not affected by rat age. |
Last Update：2024-04-09 02:00:02
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Spot supply
Product Name: Bay K 8644 Visit Supplier Webpage Request for quotationCAS: 71145-03-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-diMethyl-5-nitro-4-[2-(trifluoroMethyl)phenyl]-, Methyl ester
肼硫代酰胺,N-2-丙烯基-
肼硫代酰胺,N-2-丙烯基-